Description
IgG4 is a subclass of immunoglobulin G antibodies. Mouse monoclonal IgG4 [HP6025] targets the Fc region of human IgG4. IgG4 is beneficial for diagnosing IgG4-related systemic illness (IgG4-RSD). IgG4-RSD, or IgG4-related sclerosing disease, manifests in various organs and is characterized by lymphoplasmacytic infiltration, mass formation, sclerosis, obliterative phlebitis, and elevated levels of IgG4+ plasma cells, along with a high IgG4+/IgG+ ratio, generally exceeding 30%.
IgG4 is overexpressed in inflammatory pseudotumor (IPT) and underexpressed in inflammatory myofibroblastic tumor (IMT). IgG4 may serve as a valuable differential marker in conjunction with IgG (the IgG4+/IgG+ plasma cell ratio is elevated in IPT) and ALK (which is positive in IMT).
In pulmonary nodular lymphoid hyperplasia (PNLH), there is an elevated quantity of IgG4+ plasma cells and an increased ratio of IgG4+ to IgG+ plasma cells relative to other pulmonary lymphoid proliferations. These attributes may assist in differentiating PNLH from low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue (BALT).
Specifications
| Source | Mouse Monoclonal |
|---|---|
| Species Reactivity | Human |
| Clone | HP6025 |
| Isotype | IgG1 |
| Antigen | Fc region of human IgG4 |
| Localization | Cytoplasmic |
| Positive Control | Spleen |
