Description
IMP3 (insulin-like growth factor II mRNA-binding protein 3) is a 580 amino acid
oncofetal RNA-binding protein featuring four K homology domains, encoded by a
4350 bp mRNA transcript derived from the IGF2BP3 gene located on chromosome
7p11.5 .Recent publications highlight its significance as a novel biomarker in several
cancer types, with results indicating that IMP3 may be integral to malignant
transformation. The cytoplasmic expression of IMP3 is correlated with a more
aggressive phenotype in various malignancies, including triple-negative (basal-like)
breast cancer, colon cancer, lung cancer, and prostate cancer. IMP3 has been
utilized to differentiate between benign and malignant malignancies and has been
identified as a marker of high-grade dysplasia in esophageal adenocarcinoma.
