Description
The homeobox gene CDX2 genes for a transcription factor that is exclusive to the intestines. Metastatic colorectal denocarcinoma can be distinguished from tumors of uncertain origin using CDX2, and it has also been helpful in etermining the gastrointestinal origin of carcinoids and adenocarcinomas. CDX2 outperforms villin and CK20 in terms of specificity and sensitivity. Malignant germ cell tumors of the testes, cholangiocarcinoma, bladder adenocarcinoma, and mucinous ovarian cancer are among the cancers that express CDX2. Elevated levels of CDX2 expression were observed only in extremely rare cases of carcinomas of the genitourinary and gynecologic tracts, breast, lung, and head and neck malignancies. Recent research has demonstrated that a rabbit monoclonal antibody to CDX2 is a more sensitive clone than previous CDX2 monoclonal antibodies produced in mice. The data also showed that the number of false negatives was lower when using rabbit monoclonal CDX2. When contrasted with other monoclonal CDX2 antibodies for mice, the specificity was omparable. Nevertheless, a marginally greater proportion was hown by rabbit monoclonal CDX2 in specific malignancies. When used with CK7, TTF-1, and CDH1, a panel of CDX2 antibodies can greatly enhance their overall specificity.
