c-myc
ZR355/Rabbit/Monoclonal
Gene Bio Solution c-myc Antibody. Gene bio solution’s recombinant rabbit antibody recognizes c-myc, a protein involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.
c-myc is a transcription factor of 64-67kDa. The Gene bio solution’s c-myc antibody epitope between aa 410-419 (EQKLISEEDL), which is a specific portion of an alpha helical region of human c-myc protein. As a result, the c-myc antibody shows no cross-reaction with v-myc.
c-myc is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-myc is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-myc dysregulation induces lymphomagenesis by loss of the tight control of c-myc expression, leading to overexpression of intact c-myc protein, in contrast to the somatic mutations or fusion proteins seen in many other oncogenes. Dysregulation of c-myc in B-cell lymphomas occurs either as a primary event in Burkitt lymphoma, or secondarily in aggressive lymphomas such as diffuse large B-cell lymphoma, plasmablastic lymphoma, mantle cell lymphoma, or double-hit lymphoma.
Performing immunohistochemical stain for c-myc expression is important for prognosis in diffuse large B-cell lymphoma (DLBCL), as DLBCLs with expression of both c-myc and B-cell lymphoma 2 protein (BCL2) have worse clinical outcome than other DLBCL, NOS treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP).
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