Description
ALK Antibody (p80) identifies the formalin-resistant epitope of the native anaplastic lymphoma kinase (ALK) protein. ALK antibody specifically identifies t(2;5)-positive cells, resulting in pronounced cytoplasmic staining accompanied by nuclear staining. Anaplastic large cell lymphoma (ALCL) is a diverse collection of diseases characterized by morphology, immunophenotyping, and clinical presentation, which can complicate diagnosis due to its resemblance to Hodgkin’s lymphoma. Studies indicate that ALK mostly stains CD30+ ALCL. It has been demonstrated to not stain Hodgkin’s disease (Reed-Sternberg cells). ALK may be utilized in conjunction with CD15, CD30, TIA-1, and EMA in a panel.
Specifications
| Weight | N/A |
|---|---|
| Dimensions | N/A |
| Intended Use | RUO |
| Source | Mouse Monoclonal |
| Species Reactivity | Human |
| Clone | 5A4 |
| Isotype | IgG1 |
| Antigen | AA419-520 of NPM-ALK transcript |
| Localization | Cytoplasmic and nuclear staining (dot-like) |
| Positive Control | Anaplastic large cell lymphoma |
