Description
CD15 is present on greater than 90% of granulocytes including neutrophils and eosinophils, and to a lesser degree, on monocytes. CD15 is expressed in Reed Sternberg cells of Hodgkin’s disease (of the nodular sclerosis, mixed cellularity and
lymphocyte-depleted subtypes), and certain types of epithelial cells. It is generally agreed that the Reed-Sternberg cell variants in lymphocyte-predominant Hodgkin’s disease are not reactive with CD15. Positive staining for CD15 combined with a negative reaction for lymphocytic markers may provide support for Hodgkin’s disease.
