Description
CD4 is expressed in the majority of T-cell lymphomas, including mycosis fungoides (2). CD4 has been used in lymphoma panels that include CD3, CD5, CD8, CD7 and TIA-1 (2-3). A panel consisting of CD4(+), CD2(-) and CD56(+) antibodies was also used to help identify agranular natural killer cell lymphoma of the skin (4). A CD4 assessment may be useful in HIV-infected individuals, as HIV infection depletes intestinal CD4(+) T cells and has a strong association with the level of systemic CD4(+) T cell activation (5). Tumor infiltrating CD4 T cells may also be a prognostic factor for the strategy of early antitumor immunity (6).
Specifications
| FORMAT | Concentrate, Predilute, VALENT |
|---|---|
| VOLUME | 0.1 ml, 1.0 ml, 20 ml, 6.0 ml |
| INTENDED USE | RUO |
| SOURCE | Mouse Monoclonal |
| CLONE | 4B12 |
| ISOTYPE | IgG1/kappa |
| ANTIGEN | Prokaryotic recombinant protein corresponding to the external domain of the CD4 molecule |
| LOCALIZATION | Cell Membrane |
| POSITIVE CONTROL | Tonsil |
