CDX2 [BC39]

CDX2 is a homeobox gene that encodes a transcription factor specific to the gut and is expressed in the nucleus of intestinal epithelial cells, from the duodenum to the rectum. The CDX2 protein is present in both primary and metastatic colorectal carcinomas. It has also been recognized in primary ovarian mucinous tumors and metastatic mucinous carcinomas affecting the ovary. Research indicates that the CDX2 marker has more specificity and sensitivity than CK20. In-house experiments indicate that CDX2 [BC39] demonstrated comparable or enhanced sensitivity relative to clone CDX2-88, while maintaining nearly equivalent specificity.