Description
Claudin-4, a tight junction protein, is encoded by the CLDN4 gene and serves as a receptor for Clostridium perfringens enterotoxin. The utility of Claudin-4 expression varies according to the cancer type. Claudin-4 has demonstrated 99% specificity in differentiating adenocarcinoma from malignant mesothelioma in malignant effusions. Basal-like cancers exhibited overexpression of Claudin-4. The absence of Claudin-4 was observed in 69% of advanced gastric tumors and was associated with poor differentiation.
Specifications
| Intended Use | RUO |
|---|---|
| Format | Concentrate, Predilute, Q Series |
| Volume | 0.1 ml, 0.5 ml, 6.0 ml, 7 ml |
| Source | Mouse Monoclonal |
| Clone | 3E2C1 |
| Isotype | IgG1 |
| Antigen | Synthetic peptide corresponding to a 22 amino acid sequence derived from the C-terminal region of human Claudin-4 |
| Localization | Cell Membrane |
| Positive Control | Colon carcinoma or breast carcinoma |
