Desmoglein 3 + CK5

Desmoglin 3 (DSG3) is frequently overexpressed in multiple squamous cell carcinomas (SqCC). In investigations of lung squamous cell carcinoma, DSG3 has exhibited a sensitivity of 85-99% and a specificity of 98-100% in distinguishing lung adenocarcinoma. Multiple studies have demonstrated CK5/6 as a sensitive marker for lung squamous cell carcinoma (SqCC). Two studies utilizing a combination of DSG3 and CK5 antibodies demonstrated sensitivities of 93% and 100% for lung squamous cell carcinoma, with a specificity of 100% against lung adenocarcinoma. Research indicates that a DSG3 and CK5 combination offers enhanced sensitivity and specificity relative to other markers for lung squamous cell carcinoma (SqCC).

Specifications