FOXP3 [86D]

FOXP3 [86D] is a mouse monoclonal antibody designed for laboratory applications to
qualitatively identify FOXP3 protein using immunohistochemistry (IHC) in formalin-fixed
paraffin-embedded (FFPE) human tissues. The clinical assessment of any staining or its
absence must be supplemented by morphological analyses with appropriate controls
and should be considered in conjunction with the patient’s clinical history and other
diagnostic evaluations by a certified pathologist.
FOXP3 is a member of the forkhead transcription factor family that plays a role in the
regulation, activation, and differentiation of T-cells. FOXP3 is established as a master
regulatory gene for the generation and activity of CD4+/CD25+ regulatory T-cells. In
immunohistochemistry, FOXP3 has been identified as a particular marker for adult Tcell
leukemia/lymphoma. Elevated levels of circulating regulatory T cells have been
linked to disease development in melanoma, as well as breast and lung malignancies.
In contrast, the presence of FOXP3+ regulatory T cells in invasive tumors has been
linked to survival across several malignancies. In colon malignancies, a high prevalence
of FOXP3+ infiltrates has been demonstrated to be a favorable prognostic indication.
Individuals with elevated FOXP3 expression in Crohn’s disease demonstrate an
improved response to infliximab treatment. In allograft recipients, FOXP3 cell numbers
may be beneficial for enhancing post-transplant care.

Specifications