Description
Other types of tissues that express GCDFP-15 are axillary sweat glands and submandibular salivary glands. Mammaglobin (rabbit monoclonal), a mammary-specific member of the uteroglobin family, is known to be overexpressed in human breast cancer. Studies suggest that mammaglobin is one of the first relatively mammary-specific and mammary-sensitive markers. In normal breast tissue, mammaglobin labels breast ductal and lobular epithelial cells. However, mammaglobin is expressed in a higher percentage of lobular carcinoma versus ductal cell carcnimoma. Studies have also shown that mammaglobin was not altered at the metastatic lymph node site. Mammaglobin is expressed in non-breast cancer sites such as endometroid carcinomas (39%), endocervical adenocarcinoma in situ (45%), sweat gland carcinomas (40%), salivary gland carcinoma (20%), melanoma (6%) and is also found in a small percentage of ovarian carcinomas and pancreatic adenocarcinomas.
Mammaglobin is expressed in 50-60% of metastatic breast cancers while GCDFP-15 is expressed in approximately 20-25%. Mammaglobin is a more sensitive marker than GCDFP-15 for breast carcinoma; however, it lacks the specificity of GCDFP-15. The combination of GCDFP-15 and Mammaglobin and other markers may help to establish the correct interpretation of metastatic breast carcinoma.
Specifications
| WEIGHT | N/A |
|---|---|
| DIMENSIONS | N/A |
| INTENDED USE | RUO |
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal, Rabbit Monoclonal |
| CLONE | D6 (GCDFP-15) and 31A5 (Mammaglobin) |
| ISOTYPE | IgG2a (GCDFP-15) and IgG (Mammaglobin) |
| ANTIGEN | GCDFP-15 and Mammaglobin |
| LOCALIZATION | GCDFP-15 (Cytoplasmic): Brown Mammaglobin (Cytoplasmic): Red |
| POSITIVE CONTROL | Breast |
