The Heat Pretreatment Solution Citric (PT1) is intended to be used for heat pretreatment of formalin-fixed, paraffin-embedded specimens in fluorescence in situ hybridization (FISH) applications. The Heat Pretreatment Solution Citric is intended to be used in combination with Gene bio Solution probes and implementation kits. The product is intended for professional use only. All tests using the product should be performed in a certified, licensed anatomic pathology laboratory under the supervision of a pathologist/human geneticist by qualified personnel.