HPV Cocktail Broad Spectrum

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The broad spectrum HPV antibody was produced (1H8) against SDS-disrupted bovine papillomavirus type 1 (BPV-1) and used to identify the product of the L1 open reading frame (ORF) of BPV-1. IH8 was found to be reactive with purified major capsid protein (MCP). The antibody was tested with ELISA and with an immunofluorescent technique and detected HPV-1, 6, 11, 16, 18, and 31 in formalin-fixed paraffin embedded biopsy specimens.

Category: Primary Antibodies

Description

Description

The CAMVIR-1 antibody was raised against the major capsid protein L1 of human papillomavirus type 16, using a recombinant vaccinia virus that expresses the L1 protein, as a target for screening. This antibody reacted with a 56 kilodalton protein in cells infected with L1-vaccinia virus, and the protein was present in HPV16. A panel of p16 and Ki-67 can be used for further evaluation. CAMVIR-1 may also be used separately for phenotyping HPV-16. Other HPV isotypes may also be reactive with the Broad Spectrum HPV antibody, but have not been tested.

Specifications

INTENDED USE	RUO
SPECIES REACTIVITY	Human
SOURCE	Mouse Monoclonal
CLONE	BPV-1/1H8 + CAMVIR-1
ISOTYPE	IgG + IgG2a
ANTIGEN	HPV Cocktail Broad Spectrum (HPV-1, 6, 11, 16-16, 18 and 31)
LOCALIZATION	Nuclear
POSITIVE CONTROL	Infected cervical biopsy