Description
Immunoglobulin G (IgG) is an antibody isotype produced by plasma cells, consisting
of four peptide chains: two identical heavy chains and two identical light chains,
organized in a Y-shaped configuration characteristic of antibody monomers. In
humans, IgG comprises four subclasses that vary just slightly in their amino acid
makeup . IgG constitutes over 75% of serum immunoglobulins in humans, making it
the predominant antibody isotype in circulation. Anti-IgG has demonstrated utility in
evaluating renal biopsies, autoimmune diseases , identifying plasma cell neoplasms ,
and diagnosing non-Hodgkin lymphomas. The proportion of IgG4+ plasma cells to
IgG+ plasma cells is deemed significant in diagnosing IgG4-related diseases.
Specifications
| Intended Use | RUO |
|---|---|
| Format | Concentrate, Predilute |
| Volume | 0.1 ml, 0.5 ml, 6.0 ml |
| Clone | RWP49 |
| Isotype | IgG1 |
| Source | Mouse Monoclonal |
| By Letter | H |
