Description
Achaete-scute complex homolog-1 (ASCL1), referred to as mASH1 in rodents and
hASH1 in humans, is a basic helix-loop-helix transcription factor essential for
neuroendocrine cell development. Neuroendocrine carcinomas may develop in various
locations, including the lung, gastrointestinal system, prostate, and skin. High-grade,
poorly differentiated neuroendocrine carcinomas are categorized as neuroendocrine
carcinomas (NECs) and are differentiated from low-grade neuroendocrine tumors
(NETs). Traditional neuroendocrine markers, including chromogranin and CD56, are
unable to differentiate neuroendocrine carcinomas (NECs) from neuroendocrine tumors
(NETs) . Research indicates that the mouse monoclonal antibody MASH1 [24B72D11.1]
effectively stains hASH1 in human tissues and differentiates neuroendocrine cells
(NECs) from neuroendocrine tumors (NETs) across many locations . MASH1 has
demonstrated the ability to differentiate large cell neuroendocrine carcinomas (LCNECs)
and small cell lung carcinomas (SCLCs) from other lung cancer subtypes . MASH1 has
additionally been employed to distinguish small cell lung cancer from Merkel cell
carcinoma. MASH1, although not a tissue-specific marker, may aid in differentiating
neuroendocrine carcinomas from neuroendocrine tumors in poorly differentiated
instances.
