Description
The E3 ubiquitin ligase encoded by the MDM2 gene, which is found in chromosome region 12q15, functions as a significant negative regulator of the tumour suppressor p531. Many human tumours, including soft tissue sarcomas, osteosarcomas2, gliomas, non-small cell lung cancer, gastric, and breast carcinomas, overexpress MDM2 as a result of chromosomal region amplification.
