Description
Since NKX2.2 expression has been detected in gut neuroendocrine tumors, it may be used as a marker for research on gastrointestinal neuroendocrine tumors. More recently, array-based gene expression research revealed that the NKX2.2 protein is differentially elevated in Ewing sarcoma and is a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma. With a sensitivity of 93% and a specificity of 89%, it serves as a useful marker for Ewing sarcoma and facilitates the differential diagnosis of small round cell tumors.
