Description
The mouse monoclonal antibody p40 [BC28] identifies an epitope exclusive to the p40
protein and may serve as an alternative in instances where p63 has typically been
employed. p63 [4A4] identifies both the p63 and p40 proteins. Consequently, p63
exhibits specificity limitations owing to its reactivity in a subset of lung adenocarcinomas
(ADC). Conversely, p40 is exclusively expressed in lung squamous cell carcinoma
(SqCC), providing a possibility for enhanced specificity. The p40 antibody (M) [BC28]
identifies an epitope exclusive to p40, perhaps leading to reduced reactivity in lung ADC
and enhanced specificity. Research has endorsed the regular application of p40 as a
substitute for p63. Unlike the rabbit polyclonal p40, p40 [BC28] does not exhibit
staining in macrophages.
