Description
PAX2 (Paired Box Gene 2) is a transcription factor crucial for the development of several tissues and organs, particularly during embryogenesis. It is part of the PAX family of genes, which are characterized by the presence of a conserved DNA-binding motif called the paired box. PAX2 plays an essential role in the development of the kidneys, eyes, ears, and parts
of the central nervous system (CNS). Specifically, it regulates the formation and differentiation of renal tubules, the ureteric bud, and the retina. PAX2 expression is tightly regulated during embryonic development and is typically downregulated in adulthood, although it can be re-expressed in certain diseases, including cancers.
