The Pepsin Solution (ES1) is intended to be used for proteolytic pretreatment of formalin-fixed, paraffin-embedded specimens in in situ hybridization (ISH) applications. The Pepsin Solution is intended to be used in combination with Gene bio Solution probes and tissue implementation kits. The product is intended for professional use only. All tests using the product should be performed in a certified, licensed anatomic pathology laboratory under the supervision of a pathologist/human geneticist by qualified personnel.