SOX11

The SOX11 antibody (SRY (Sex Determining Region Y)-Box 11) belongs to the SOX family of transcription factors and plays a role in regulating embryonic development and determining cell fate. Diagnosing mantle cell lymphoma (MCL) can be challenging, particularly in the absence of t(11;14) translocation and cyclin D1 overexpression. The transcription factor SOX11 serves as a crucial diagnostic marker, as it is expressed in the majority of MCLs, especially in all reported cyclin D1-negative MCLs. The novel mouse monoclonal SOX11-C1 antibody exhibits nuclear staining and provides enhanced sensitivity and specificity relative to earlier SOX11 antibodies in immunohistochemical detection of MCL. Moreover, flow cytometry examination of blood and tissue specimens utilizing SOX11-C1 may facilitate a practical method for the early diagnosis and monitoring of MCL patients . SOX11 expression has been demonstrated to be a good prognostic indicator in glioblastoma.

Specifications