Description
The SOX2 gene encodes a protein belonging to the SRY-related HMG-box (SOX) family of transcription factors. SOX2 is expressed in multipotent neural stem cells and may facilitate the identification of cells capable of self-renewal and multipotent differentiation. SOX2 has been identified as a poor prognostic indicator linked to aggressive phenotypes in breast, head and neck, gastric, colorectal, and bladder cancers. In small cell lung tumors, SOX2 was associated with an unfavorable prognosis. In contrast, SOX2 is highly expressed in a significant proportion of lung squamous cell carcinomas and has been identified as an independent favorable prognostic indicator.
Specifications
| Intended Use | RUO |
|---|---|
| Format | Concentrate, Predilute |
| Volume | 0.1 ml, 1.0 ml, 6.0 ml |
| Source | Mouse Monoclonal |
| Clone | BC36, Biocare Clone |
| Isotype | IgG1/kappa |
| Antigen | SOX2 |
| Localization | Nuclear |
| Positive Control | Lung squamous cell carcinoma |
