Description
Topoisomerase II alpha (Topo IIa) is crucial for DNA synthesis, RNA transcription, and chromosomal segregation during mitosis. It is identified as a sensitive and specific marker for the late S, G2, and M stages in both transformed and developmentally controlled normal cells. Topo IIa is associated with drug resistance in tumor cells and is demonstrated to be over-expressed in numerous human malignancies. The primary mechanism of resistance to many chemotherapeutic drugs is the reduced expression of Topo IIa.
Specifications
| Weight | N/A |
|---|---|
| Dimensions | N/A |
| Intended Use | RUO |
| Species Reactivity | Human |
| Source | Mouse Monoclonal |
| Clone | 31 |
| Isotype | Mouse IgG1 |
| Antigen | Topoisomerase II alpha |
| Localization | Nuclear |
| Positive Control | Cervix or tonsil |
